Phenotypes Associated with This Genotype

Genotype
MGI:3819181

• Allelic Composition: Hexim1^Gt(XB322)Byg/Hexim1^Gt(XB322)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:141643 )

• fewer than expected mice are present after E16.5

cardiovascular system

abnormal coronary artery morphology ( J:141643 )

• at E15.5, coronary arteries exhibit disorganized branching patterns and myocardium vascularization is reduced compared to in wild-type mice

thin myocardium compact layer ( J:141643 )

• at E17.5, the myocardial compact layer is reduced in thickness or locally lost unlike in wild-type mice

abnormal interventricular septum morphology ( J:141643 )

• at E15.5 but not E13.5, proliferation of cells within the intraventricular septum is increased compared to in wild-type mice

increased heart ventricle size ( J:141643 )

• at E17.5

thin ventricular wall ( J:141643 )

• at E17.5, the ventricular wall is thinner than normal due to increased apoptosis compared to in wild-type mice

dilated cardiomyopathy ( J:141643 )

• at E17.5

muscle

thin myocardium compact layer ( J:141643 )

• at E17.5, the myocardial compact layer is reduced in thickness or locally lost unlike in wild-type mice

dilated cardiomyopathy ( J:141643 )

• at E17.5