Phenotypes Associated with This Genotype

Genotype
MGI:3819934

• Allelic Composition: Tg(Lck-VIPR2)1Ejg/0
• Genetic Background: C57BL/6-Tg(Lck-VIPR2)1Ejg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:127974 )

• serum levels of eosinophils are significantly higher than in wild-type

increased IgE level ( J:127974 )

• serum levels are significantly higher than in wild-type

• levels of antigen-specific IgE during primary and secondary responses to immunization with TNP-KLH are significantly higher than in controls

increased IgG1 level ( J:127974 )

• serum levels are significantly higher than in wild-type

• levels of antigen-specific IgE during primary and secondary responses to immunization with TNP-KLH are marginally higher than in controls

increased susceptibility to type I hypersensitivity reaction ( J:127974 )

• mice show greater immediated cutaneous hypersensitivity to antigen challenge indicated by significantly greater footpad swelling after 60 minutes than in controls

• much higher active cutaneous anaphylaxis reaction (swelling) is elicited in flank skin of secondarily immunized mice compared to controls at 30 minutes after TNP-CGG challenge

decreased susceptibility to type IV hypersensitivity reaction ( J:127974 )

• antigen-specific delayed-type hypersensitivity is depressed compared to controls indicated by reduced footpad swelling at 24 hours after immunization with NP OSu

decreased interferon-gamma secretion ( J:127974 )

• after TCR stimulation splenic CD4+ T cells produce less interferon-gamma (Ifng) than wild-type cells at 24 and 96 hours after stimulation

increased interleukin-4 secretion ( J:127974 )

• after TCR stimulation splenic CD4+ T cells produce significantly more IL4 than wild-type cells at 24 and 96 hours after stimulation

increased interleukin-5 secretion ( J:127974 )

• after TCR stimulation splenic CD4+ T cells produce significantly more IL5 than wild-type cells at 24 and 96 hours after stimulation

hematopoietic system

increased eosinophil cell number ( J:127974 )

• serum levels of eosinophils are significantly higher than in wild-type

increased IgE level ( J:127974 )

• serum levels are significantly higher than in wild-type

• levels of antigen-specific IgE during primary and secondary responses to immunization with TNP-KLH are significantly higher than in controls

increased IgG1 level ( J:127974 )

• serum levels are significantly higher than in wild-type

• levels of antigen-specific IgE during primary and secondary responses to immunization with TNP-KLH are marginally higher than in controls