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Phenotypes Associated with This Genotype
Genotype
MGI:3821710
Allelic
Composition		 B2mtm1Jae/B2mtm1Jae
Zbtb7btm1Litt/Zbtb7btm1.2Litt
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Jae mutation (8 available); any B2m mutation (121 available)
Zbtb7btm1.2Litt mutation (1 available); any Zbtb7b mutation (26 available)
Zbtb7btm1Litt mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )
• single-positive CD8+ cells are found among mature thymocytes compared to mice null for just the B2m locus that have no mature CD8+ thymocytes
abnormal double-positive T cell morphology ( J:141144 )
• an unusual double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSAlo-neg TCRbetahi) and may represent single-positive CD4+ thymoyctes that are redirected to a CD8+ T cell lineage

hematopoietic system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )
• single-positive CD8+ cells are found among mature thymocytes compared to mice null for just the B2m locus that have no mature CD8+ thymocytes
abnormal double-positive T cell morphology ( J:141144 )
• an unusual double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSAlo-neg TCRbetahi) and may represent single-positive CD4+ thymoyctes that are redirected to a CD8+ T cell lineage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory