Phenotypes Associated with This Genotype

Genotype
MGI:3821722

• Allelic Composition: Tnnt2^tm1Mmto/Tnnt2^tm1Mmto
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:141967 )

• die between E10 and E11.5

cardiovascular system

absent atrioventricular cushions ( J:141967 )

• at E9.25

failure of heart looping ( J:141967 )

• at E9.25 all sections of the heart remain in the same plane

dilated heart ( J:141967 )

• dilated heart containing fewer cells

absent heartbeat ( J:141967 )

• embryos never have a heartbeat

muscle

abnormal sarcomere morphology ( J:141967 )

• sarcomeres lack the normal hexagonal structure and instead the filaments are dispersed throughout the cytoplasm

embryo

decreased embryo size ( J:141967 )

abnormal embryonic tissue morphology ( J:141967 )

• embryos are more translucent and appear to contain fewer cells

growth/size/body

decreased embryo size ( J:141967 )