Analysis Tools
mortality/aging
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• by P15 less than 3% of mice are viable
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• fewer than expected mice are present at E12.5 to E13.5
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embryo
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• at E8.5 to E9.5, some embryos develop outside of the yolk sac
• during head fold development, the neuroectoderm replaces the definitive ectoderm and the anterior portion of the embryo breaks through the yolk sac unlike in wild-type mice
• however, embryonic patterning and cell proliferation, apoptosis and migration during early development are normal
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• in some mice at E8.5 to E9.5
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• at E8.5 to E9.5, some mice exhibit asymmetric head folds while others exhibit heads that develop outside of the yolk sac
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• some mice exhibit an anterior neural tube closure defect
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• in some mice at E8.5 to E9.5
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• 79% of mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm
• disruption of the basement membrane precedes disruption in the anterior visceral endoderm and induces epithelial-mesenchymal transition unlike in wild-type mice
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nervous system
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• at E8.5 to E9.5, some mice exhibit asymmetric head folds while others exhibit heads that develop outside of the yolk sac
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• some mice exhibit an anterior neural tube closure defect
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cardiovascular system
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• in some mice at E8.5 to E9.5
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growth/size/body
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• some mice exhibit failure of the ventral body to close
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cellular
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• 79% of mice exhibit a rupture in the basement membrane that results in holes in the anterior visceral endoderm
• disruption of the basement membrane precedes disruption in the anterior visceral endoderm and induces epithelial-mesenchymal transition unlike in wild-type mice
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