Analysis Tools
cellular
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• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice
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reproductive system
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• in superovulation experiments, mice ovulate half as many oocytes as wild-type mice
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• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
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• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
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• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
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• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
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• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice
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homeostasis/metabolism
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• at 8 months
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• at 8 months
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mortality/aging
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• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice
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endocrine/exocrine glands
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• at 3 months, mice contain luteinizing follicles that encompass trapped oocytes unlike in wild-type mice
• at 8 months, mice exhibit more severe follicular abnormalities than at 3 moths with aberrant cumulus cell-oocytes unlike in wild-type mice
|
|
|
• at 3 months, fewer antral follicles are present compared to in wild-type ovaries
|
|
|
• at 3 months, a marker of follicular atresia accumulates unlike in wild-type ovaries
|
|
|
• treatment with pregnant mare serum gonadotropin (PMSG) induces only minimal cumulus expansion unlike in similarly treated wild-type mice and few cumulus cells attach to oocytes
• in culture, cumulus cells undergo disorganized and limited expansion in response to EGF compared to similarly treated wild-type cells
• in culture, cumulus cells stimulated by EGF detach from the cumulus oocyte complexes and attach to the culture plate leaving 18% of oocytes denuded unlike wild-type cells
|
|
|
• females exhibit reduced fertility and premature ovarian failure becoming infertile after 4 months of breeding unlike in wild-type mice
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