Phenotypes Associated with This Genotype

Genotype
MGI:3822910

• Allelic Composition: Nfkb1^tm1Sley/Nfkb1^tm1Sley
• Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased NK T cell number ( J:142340 )

• there are slightly fewer thymic TCRbeta⁺NK1.1⁺ NKT cells

• the number of thymic CD1d-dependent NKT is also reduced

decreased memory T cell number ( J:142340 )

• reconstitution of wild-type mice with mutant bone marrow leads to lower CD4⁺ memory T cells in the spleen and lymph nodes compared to controls reconstituted with wild-type bone marrow

decreased regulatory T cell number ( J:142340 )

• reconstitution of wild-type mice with mutant bone marrow leads to 3-fold lower FoxP3⁺ CD4⁺ regulatory T cells in the spleen and lymph nodes compared to controls reconstituted with wild-type bone marrow

hematopoietic system

decreased NK T cell number ( J:142340 )

• there are slightly fewer thymic TCRbeta⁺NK1.1⁺ NKT cells

• the number of thymic CD1d-dependent NKT is also reduced

decreased memory T cell number ( J:142340 )

• reconstitution of wild-type mice with mutant bone marrow leads to lower CD4⁺ memory T cells in the spleen and lymph nodes compared to controls reconstituted with wild-type bone marrow

decreased regulatory T cell number ( J:142340 )

• reconstitution of wild-type mice with mutant bone marrow leads to 3-fold lower FoxP3⁺ CD4⁺ regulatory T cells in the spleen and lymph nodes compared to controls reconstituted with wild-type bone marrow