Phenotypes Associated with This Genotype

Genotype
MGI:3829375

• Allelic Composition: Glrx3^{Gt(RRF094)Byg}/Glrx3^{Gt(RRF094)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:143577 )

• mice die between E12.5 and E14.5; none are recovered past E14.5

embryonic lethality during organogenesis, complete penetrance ( J:190794 )

• by E13.5

embryonic lethality during organogenesis, incomplete penetrance ( J:143577 )

• mice die between E12.5 and E14.5

cardiovascular system

pericardial effusion ( J:190794 )

• in some mice at E12.5

intracranial hemorrhage ( J:143577 )

• at E12.5, mice exhibit hemorrhages in the head

growth/size/body

decreased embryo size ( J:143577 , J:190794 )

• at E12.5 (J:143577)

• at E12.5 (J:190794)

embryo

decreased embryo size ( J:143577 , J:190794 )

• at E12.5 (J:143577)

• at E12.5 (J:190794)

open neural tube ( J:190794 )

• open anterior neural tube in some mice at E12.5

cellular

binucleate ( J:190794 )

• more binucleated cells are seen in cultured MEFs

abnormal cell cycle ( J:190794 )

• in culture MEFs show an increase in the proportion of cells in the G2/M phase and more binucleated cells are seen

abnormal cell death ( J:190794 )

• MEFs do not survive beyond passage 4

decreased fibroblast proliferation ( J:190794 )

• in MEFs

nervous system

intracranial hemorrhage ( J:143577 )

• at E12.5, mice exhibit hemorrhages in the head

open neural tube ( J:190794 )

• open anterior neural tube in some mice at E12.5

homeostasis/metabolism

pericardial effusion ( J:190794 )

• in some mice at E12.5