Phenotypes Associated with This Genotype

Genotype
MGI:3830301

• Allelic Composition: Adcy6^tm1Hkh/Adcy6^tm1Hkh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart left ventricle muscle contractility ( J:143138 )

• reduced dobutamin affect on left ventricular fractional shortening

• reduced left ventricular ejection fraction

abnormal heart left ventricle pressure ( J:143138 )

• left ventricular pressure development is reduced in isolated perfused hearts

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:143138 )

• calcium ion uptake by the sarcoplasmic reticulum is reduced at a variety of calcium concentrations

• caffein stimulated calcium transients in cardiac myocytes are reduced around 50%

muscle

decreased heart left ventricle muscle contractility ( J:143138 )

• reduced dobutamin affect on left ventricular fractional shortening

• reduced left ventricular ejection fraction