Analysis Tools
mortality/aging
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• all embryos die by E12.5 due to severe hemorrhaging within the central nervous system
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cardiovascular system
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• in E12.5 embryos, endothelial cells and pericytes are entirely absent from the neuroepithelium
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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nervous system
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• hemorrhaging is detected throughout the developing brain of E12.5 embryos
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• hemorrhaging is detected throughout the developing spine of E12.5 embryos
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• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos
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