Phenotypes Associated with This Genotype

Genotype
MGI:3831540

• Allelic Composition: Sac3d1^tm1Hnaka/Sac3d1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:144601 )

• mast cells proliferate faster in response to low and high doses of IL-3

hematopoietic system

abnormal bone marrow cell morphology/development ( J:144601 )

• bone marrow cells cultured in vitro with IL-3 and GM-CSF have a faster proliferation rate than controls

abnormal common myeloid progenitor cell morphology ( J:144601 )

• there is about a 30% increase in the number of GM progenitors in the bone marrow compared to controls

increased erythroid progenitor cell number ( J:144601 )

• 3-fold increase in the numbers BFU-E progenitors in the bone marrow compared to controls

• there is about a 30% increase in the number of GM progenitors in the bone marrow compared to controls

abnormal mast cell physiology ( J:144601 )

• mast cells proliferate faster in response to low and high doses of IL-3