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Phenotypes Associated with This Genotype
Genotype
MGI:3834445
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (90 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre

respiratory system
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory