Analysis Tools
cellular
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• spontaneous mutation frequency for mixed spermatogenic cells
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• spontaneous mutation frequency for mixed spermatogenic cells from 9-month-old double mutant mice is 2-fold higher than for wild-type Apex1 hemizygous Tg mice
• spontaneous mutation frequency observed in liver samples in 3-month-old animals is significantly higher compared to age matched wild-type Apex1 hemizygous Tg mice; a further 1.5-fold increase is observed in samples from 9-month-old animals
• spontaneous mutation frequency observed in liver samples in 9-month-old animals is significantly higher compared to 3-month-old mice of the same genotype, suggesting an age-related increase in frequency
• spontaneous mutation frequency observed in spleen samples from 3-month-old mice is 2-fold higher than in controls and an additional 2-fold increase is found in samples from 9-month-old mice
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homeostasis/metabolism
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• spontaneous mutation frequency for mixed spermatogenic cells from 9-month-old double mutant mice is 2-fold higher than for wild-type Apex1 hemizygous Tg mice
• spontaneous mutation frequency observed in liver samples in 3-month-old animals is significantly higher compared to age matched wild-type Apex1 hemizygous Tg mice; a further 1.5-fold increase is observed in samples from 9-month-old animals
• spontaneous mutation frequency observed in liver samples in 9-month-old animals is significantly higher compared to 3-month-old mice of the same genotype, suggesting an age-related increase in frequency
• spontaneous mutation frequency observed in spleen samples from 3-month-old mice is 2-fold higher than in controls and an additional 2-fold increase is found in samples from 9-month-old mice
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