Phenotypes Associated with This Genotype

Genotype
MGI:3834458

• Allelic Composition: Apex1^tm1Djc/Apex1⁺
• Genetic Background: involves: 129X1/SvJ * NTac:NIHS

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:92957 )

♂ • in 9-month-old mice numbers of tubules containing apoptotic cells is higher than in controls (32.8% vs 19.3%); proportion of apoptotic spermatogonia is also higher (54.4% vs 17.3%) at 9 months

liver/biliary system

abnormal liver morphology ( J:92957 )

• at 9 months, centrilobular fatty changes surrounding the central vein are common (in 50% of animals) compared to wild-type controls

reproductive system

abnormal seminiferous tubule morphology ( J:92957 )

♂ • in 9-month-old mice numbers of tubules containing apoptotic cells is higher than in controls (32.8% vs 19.3%); proportion of apoptotic spermatogonia is also higher (54.4% vs 17.3%) at 9 months