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Phenotypes Associated with This Genotype
Genotype
MGI:3834603
Allelic
Composition
Kif22tm1.1Tya/Kif22tm1.1Tya
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif22tm1.1Tya mutation (0 available); any Kif22 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% fewer than expected blastocysts are recovered at E3.5
• however, the number of 2 to 8 cell staged mice is normal

embryo
• first and second polar bodies are retained within fertilized oocyte and results in multi-pronuclei at the 1-cell stage
• anaphase chromosome compaction results in the formation of multinucleated cells during oocyte meiosis II and early embryogenesis

cellular
• anaphase chromosome compaction results in the formation of multinucleated cells during oocyte meiosis II and early embryogenesis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory