mortality/aging
• 50% fewer than expected blastocysts are recovered at E3.5
• however, the number of 2 to 8 cell staged mice is normal
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embryo
• first and second polar bodies are retained within fertilized oocyte and results in multi-pronuclei at the 1-cell stage
• anaphase chromosome compaction results in the formation of multinucleated cells during oocyte meiosis II and early embryogenesis
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cellular
• anaphase chromosome compaction results in the formation of multinucleated cells during oocyte meiosis II and early embryogenesis
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