Phenotypes Associated with This Genotype

Genotype
MGI:3834761

• Allelic Composition: Trpv1^tm1Jul/Trpv1^tm1Jul
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:104828 )

N • mice exhibit normal circadian core body temperature, response to warm or cold exposure, and ethanol-induced hypothermia

impaired febrile response ( J:104828 )

• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:144978 )

• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks

• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous

renal/urinary system

abnormal urination ( J:78707 )

• increased frequency of non-voiding contractions

• the frequency of and strength voiding contractions were similar those of wild-type littermates

neoplasm

increased incidence of tumors by chemical induction ( J:144978 )

• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks

• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous

immune system

decreased susceptibility to endotoxin shock ( J:104828 )

• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice