Phenotypes Associated with This Genotype

Genotype
MGI:3834976

• Allelic Composition: Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz
• Genetic Background: involves: 129S4/SvJae * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:48196 )

• mice are more resistant to acetaminophen toxicity than wild-type mice

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:48196 )

• mice are more resistant to acetaminophen toxicity than wild-type mice

decreased physiological sensitivity to xenobiotic ( J:48196 )

• following administration of 200 and 400 mg/kg acetaminophen, mice exhibit unaltered levels of serum liver enzymes unlike wild-type mice and reduced liver damage compared to similarly treated wild-type mice