Phenotypes Associated with This Genotype

Genotype
MGI:3835857

• Allelic Composition: Gria1^tm2Rsp/Gria1^tm2Rsp; Tg(Slc6a3-icre)9075Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced conditioned place preference behavior ( J:139693 )

• mice do not lose the preference for an environment where cocaine was previously administered (i.e. conditioned place preference) even after 16 days have passed since the last cocaine dosing

nervous system

abnormal glutamate-mediated receptor currents ( J:139693 )

• there is no increase in the ratio of AMPA-/NMDA- mediated receptor currents for the ventral tegmental area isolated from mice treated with cocaine as occurs in wild-type controls

• cocaine-induced synaptic strengthening in the ventral tegmental area does not occur in these mice