Phenotypes Associated with This Genotype

Genotype
MGI:3836783

• Allelic Composition: Thrb^tm1Df/Thrb^tm1Df
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

enlarged tectorial membrane ( J:145941 )

• thickened and enlarged, most prominently in the apical turns

decreased cochlear microphonics ( J:145941 )

• severely reduced

increased or absent threshold for auditory brainstem response ( J:145941 )

• ABR thresholds for click auditory stimuli are increased in mice at 3 - 4 months of age

abnormal cochlear nerve compound action potential ( J:145941 )

• elevated compound action potential thresholds at all frequencies tested in mice at 3 - 4 months of age

• however, the shape of the compound action potential waveform is similar to controls

increased or absent distortion product otoacoustic emission threshold ( J:145941 )

• DPOAE thresholds are altered with no 2f1-f2 amplitude baseline at an f2 frequency of 16 kHz and significantly elevated thresholds at frequencies greater than 8 kHz

nervous system

decreased cochlear microphonics ( J:145941 )

• severely reduced

abnormal cochlear nerve compound action potential ( J:145941 )

• elevated compound action potential thresholds at all frequencies tested in mice at 3 - 4 months of age

• however, the shape of the compound action potential waveform is similar to controls