Phenotypes for Il6st Tg(Alb1-cre)7Gsc MGI:3837204 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Il6st^tm1Ard/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ard mutation (2 available); any Il6st mutation (80 available)
Il6st^tm1Wme mutation (2 available); any Il6st mutation (80 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:97327 )

• die within 8 hours of ConA treatment regardless of pretreatment with Il6

liver/biliary system

abnormal liver physiology ( J:97327 )

• liver damage due to ConA treatment regardless of pretreatment with Il6

abnormal liver regeneration ( J:135290 )

• maximal DNA synthesis in hepatocytes after partial hepatectomy and lipopolysaccharide treatment is reduced relative to controls

• 20% of cells as compared to 30% of cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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