Phenotypes Associated with This Genotype

Genotype
MGI:3837371

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Tg(Syn1-cre)671Jxm/0
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:145998 )

decreased circulating adrenaline level ( J:145998 )

decreased circulating noradrenaline level ( J:145998 )

endocrine/exocrine glands

increased insulin secretion ( J:145998 )

nervous system

abnormal sympathetic nervous system physiology ( J:145998 )

• sympathetic tone, as measured by Ucp1 expression and levels of epinephrine and norepinephrine, is low compared to in wild-type mice

• however, treatment with isoproterenol increases sympathetic tone