Phenotypes Associated with This Genotype

Genotype
MGI:3839250

• Allelic Composition: Prkdc^scid/Prkdc^scid; Tg(Tcrb)93Vbo/0
• Genetic Background: involves: Balb/c * C57BL/Ka * C57BL/Lia * CBA/BrA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:111476 )

• thymocytes express high levels of the transgenic TCR-beta chain on their surface that appear to be homodimers

abnormal double-positive T cell morphology ( J:111476 )

• 50% of thymocytes are CD4⁺CD8⁺ compared to scid homozygotes which have no double positive thymocytes

abnormal CD4-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal CD8-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal single-positive T cell number ( J:111476 )

• small numbers of single-positive thymocytes are in the thymus

• 3% of thymocytes are CD4⁺CD8^- and 7.9% of thymocytes are CD4^-CD8⁺

hematopoietic system

abnormal T cell differentiation ( J:111476 )

• thymocytes express high levels of the transgenic TCR-beta chain on their surface that appear to be homodimers

abnormal double-positive T cell morphology ( J:111476 )

• 50% of thymocytes are CD4⁺CD8⁺ compared to scid homozygotes which have no double positive thymocytes

abnormal CD4-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal CD8-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal single-positive T cell number ( J:111476 )

• small numbers of single-positive thymocytes are in the thymus

• 3% of thymocytes are CD4⁺CD8^- and 7.9% of thymocytes are CD4^-CD8⁺