Phenotypes Associated with This Genotype

Genotype
MGI:3840586

• Allelic Composition: Tg(KRT14-Birc5)19Gros/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:81530 )

• less transgenic mice develop skin tumors after topical application of DMBA and PMA than controls

• only 31% of mice develop tumors within 32 weeks of DMBA application compared to 43% of controls

• tumor burden is less with a mean of 1.5 tumors developing per animal compared to 2.0 in controls

• no tumor regression is observed in transgenic mice while 20% of wild-type mice have some tumor regression

• one transgenic mouse developed an aggressive squamous cell carcinoma that was not observed in the wild-type group

integument

abnormal keratinocyte physiology ( J:81530 )

• keratinocytes are resistant to apoptosis caused by topical application of DMBA

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:81530 )

• less transgenic mice develop skin tumors after topical application of DMBA and PMA than controls

• only 31% of mice develop tumors within 32 weeks of DMBA application compared to 43% of controls

• tumor burden is less with a mean of 1.5 tumors developing per animal compared to 2.0 in controls

• no tumor regression is observed in transgenic mice while 20% of wild-type mice have some tumor regression

• one transgenic mouse developed an aggressive squamous cell carcinoma that was not observed in the wild-type group