Phenotypes Associated with This Genotype

Genotype
MGI:3841112

• Allelic Composition: Nfkb1^tm1Bal/Nfkb1^tm1Bal; Tg(Tnfsf13b)1Fma/?
• Genetic Background: B6.Cg-Nfkb1^tm1Bal Tg(Tnfsf13b)1Fma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal class switch recombination ( J:113556 )

• class switch recombination mediated by T cell independent antigens or by BAFF incubation is defective in these mice

increased transitional stage B cell number ( J:113556 )

• numbers of T1 B cells in the spleen are increased almost 3-fold while T2 numbers are almost about doubled

decreased marginal zone B cell number ( J:113556 )

• marginal zone B cells are almost completely absent in the spleen

abnormal B cell activation ( J:113556 )

• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM class antibodies than wild-type controls

• the Nfkb1 null background significantly reduced the IgG2a and IgG2b responses and virtually abrogated the IgG3 and IgA responses compared to transgenic mice on a wild-type background

immune system

immune system phenotype ( J:113556 )

N • there are no elevated levels of anti-dsDNA antibodies detected in circulation compared to transgenic mice on a wild-type background that have high levels of auto-antbodies

abnormal class switch recombination ( J:113556 )

• class switch recombination mediated by T cell independent antigens or by BAFF incubation is defective in these mice

increased transitional stage B cell number ( J:113556 )

• numbers of T1 B cells in the spleen are increased almost 3-fold while T2 numbers are almost about doubled

decreased marginal zone B cell number ( J:113556 )

• marginal zone B cells are almost completely absent in the spleen

abnormal B cell activation ( J:113556 )

• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM class antibodies than wild-type controls

• the Nfkb1 null background significantly reduced the IgG2a and IgG2b responses and virtually abrogated the IgG3 and IgA responses compared to transgenic mice on a wild-type background