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Phenotypes Associated with This Genotype
Genotype
MGI:3841153
Allelic
Composition		 Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic
Background		 either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdi1tm1Ytk mutation (0 available); any Gdi1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to pharmacologically induced seizures ( J:65258 )
• more sensitive to bicuculline induced seizures than controls
abnormal excitatory postsynaptic currents ( J:65258 )
• hippocampal CA1 neurons show accumulative facilitation with repetitive stimulation at a moderate frequency
• higher excitatory post synaptic currents with repeated stimuli

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:65258 )
• more sensitive to bicuculline induced seizures than controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory