Phenotypes Associated with This Genotype

Genotype
MGI:3841624

• Allelic Composition: Ogt^tm1Gwh/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell death ( J:62279 , J:93112 )

♂ • recombined embryonic stem cells are found at 24 and 48 h following cre transduction but by 144 h all viable cells carry the unrecombined allele (J:62279)

♂ • primary embryonic fibroblasts infected with viral cre senesce and die by 12 days after infection (J:93112)

decreased cell proliferation ( J:93112 )

♂ • primary embryonic fibroblasts infected with viral cre do not form colonies of more than 10 cells indicating a failure to undergo 4 or more cell divisions