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Phenotypes Associated with This Genotype
Genotype
MGI:3841625
Allelic
Composition
Ogttm1Gwh/Y
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in annexin-V expression in single positive T cells
• about a 75% reduction in the number of T cells in the lymph nodes and spleen
• no T cells carrying the recombined allele are found in the lymph nodes or spleen
• about a 50% reduction in thymocyte cell number
• cortical double positive T cells are reduced by 50%

hematopoietic system
• increase in annexin-V expression in single positive T cells
• about a 75% reduction in the number of T cells in the lymph nodes and spleen
• no T cells carrying the recombined allele are found in the lymph nodes or spleen
• about a 50% reduction in thymocyte cell number
• cortical double positive T cells are reduced by 50%

cellular
• increase in annexin-V expression in single positive T cells

endocrine/exocrine glands
• about a 50% reduction in thymocyte cell number


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory