Phenotypes Associated with This Genotype

Genotype
MGI:3841993

• Allelic Composition: Cblb^tm1Pngr/Cblb^tm1Pngr; Itk^tm1Litt/Itk^tm1Litt
• Genetic Background: B6.129-Itk^tm1Litt Cblb^tm1Pngr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:141390 )

N • T cell proliferation in response to loading with CFSE followed by stimulation with anti-CD3 is similar to controls, unlike in either single null mouse

abnormal T cell morphology ( J:141390 )

• similar to mice homozygous null for Itk alone, most T cells have an activated/memory like phenotype

abnormal T-helper 2 cell differentiation ( J:141390 )

• partial rescue of defect in Th2 polarization compared to mice homozygous null for Itk alone

decreased T cell number ( J:141390 )

• decrease in T cell numbers similar to that in mice homozygous null for Itk alone

decreased interleukin-2 secretion ( J:141390 )

• partial rescue of decreased IL2 secretion in response to anti-CD3 anti-CD28 costimulation compared to mice homozygous null for Itk alone

hematopoietic system

abnormal T cell morphology ( J:141390 )

• similar to mice homozygous null for Itk alone, most T cells have an activated/memory like phenotype

abnormal T-helper 2 cell differentiation ( J:141390 )

• partial rescue of defect in Th2 polarization compared to mice homozygous null for Itk alone

decreased T cell number ( J:141390 )

• decrease in T cell numbers similar to that in mice homozygous null for Itk alone