Phenotypes Associated with This Genotype

Genotype
MGI:3843779

• Allelic Composition: Il6st^tm2Thir/Il6st^tm2Thir
• Genetic Background: B6.Cg-Il6st^tm2Thir

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:144906 )

• there is no suppressive effect of IL-6 family cytokines on the proliferation of osteoblasts isolated from E18.5 calvariae

• the induction of ALP activity by the IL-6 family cytokines IL-6, IL-11, and OSM is markedly suppressed in these mice

cellular

abnormal osteoblast physiology ( J:144906 )

• there is no suppressive effect of IL-6 family cytokines on the proliferation of osteoblasts isolated from E18.5 calvariae

• the induction of ALP activity by the IL-6 family cytokines IL-6, IL-11, and OSM is markedly suppressed in these mice