Phenotypes Associated with This Genotype

Genotype
MGI:3844214

• Allelic Composition: Blnk^tm1Kplm/Blnk^tm1Kplm; Plcg2^tm1.1Kuro/Plcg2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:131161 )

• 40% of B cells are dead after 2 hours in culture with 50% after 4 hours and 70% dead after 6 hours

decreased B cell number ( J:131161 )

• splenic B cell numbers are reduced to 13.5% of lymphocytes

abnormal B cell activation ( J:131161 )

• there is a 4.3 fold decrease in the concentration of calcium fluxed intracellularly after stimulus compared to wild-type controls

hematopoietic system

increased B cell apoptosis ( J:131161 )

• 40% of B cells are dead after 2 hours in culture with 50% after 4 hours and 70% dead after 6 hours

decreased B cell number ( J:131161 )

• splenic B cell numbers are reduced to 13.5% of lymphocytes

abnormal B cell activation ( J:131161 )

• there is a 4.3 fold decrease in the concentration of calcium fluxed intracellularly after stimulus compared to wild-type controls

cellular

increased B cell apoptosis ( J:131161 )

• 40% of B cells are dead after 2 hours in culture with 50% after 4 hours and 70% dead after 6 hours