Analysis Tools
immune system
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• diphtheria-treated mice develop spontaneous or induced type I diabetes mellitus at the same rate as in wild-type mice
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• diphtheria toxin-treated mice exhibit ablation of CD11b+ F4/F80+ macrophages from the spleen and lymph nodes unlike similarly treated wild-type mice
• however, CD11b+CD11c+ dendritic cells in all lymphoid organs and the pancreas of diphtheria-treated mice are spared
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hematopoietic system
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• diphtheria toxin-treated mice exhibit ablation of CD11b+ F4/F80+ macrophages from the spleen and lymph nodes unlike similarly treated wild-type mice
• however, CD11b+CD11c+ dendritic cells in all lymphoid organs and the pancreas of diphtheria-treated mice are spared
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