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Phenotypes Associated with This Genotype
Genotype
MGI:3844698
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/0
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (144 available); any Prkdc mutation (400 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:91764 )
• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes serum glucose remains high
• however, when islet and HLA-A2 positive human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes euglycemia is achieved

immune system
abnormal response to transplant ( J:91764 )
• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes engrafted islet cells are destroyed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory