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Phenotypes Associated with This Genotype
Genotype
MGI:3845377
Allelic
Composition		 Prkdcscid/Prkdcscid
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (177 available); any Prkdc mutation (417 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal splenocyte morphology ( J:91764 )
• more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface

immune system
abnormal splenocyte morphology ( J:91764 )
• more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory