Analysis Tools
mortality/aging
|
• mice exposed to vitamin A deficiency in utero start dying during the postnatal period with all mice dead by 25 days of age
|
homeostasis/metabolism
|
• following administration of a 50-mg/kg dose of retinol, there is a 10-fold decrease in retinoic acid production in the liver and a 23-fold drop in the sera compared to wild-type mice
• retinol toxicity is increased in these mice with a LD50 that is 2.2-fold less than controls
|
growth/size/body
weight loss
(
J:76055
)
|
• mice exposed to vitamin A deficiency in utero have bodyweight that deviate downward from WT at 8 days of age
• body weights beyond 6 g were not achieved before death
|
