Phenotypes Associated with This Genotype

Genotype
MGI:3846352

• Allelic Composition: Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj}; Shh^tm1Chg/Shh^tm1Chg
• Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5

abnormal diencephalon morphology ( J:73074 )

• in about half of mice development of the diencephalic vesicles is partially rescued with partial separation into 2 vesicles seen at E10.5 or E11.5

decreased motor neuron number ( J:73074 )

• absent from the spinal cord at E10.5

abnormal ventral interneuron 3 morphology ( J:73074 )

• absence of V3 interneurons at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5

growth/size/body

megacephaly ( J:73074 )

• head size is increased compared to mice homozygous null for Shh alone