Phenotypes Associated with This Genotype

Genotype
MGI:3848618

• Allelic Composition: Mogat2^tm1Far/Mogat2^tm1Far
• Genetic Background: B6.129S4-Mogat2^tm1Far

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal intestinal lipid absorption ( J:149373 )

• when fed an increased amount of fat, less lipids enter circulation compared to wild-type mice

decreased susceptibility to diet-induced obesity ( J:149373 )

• at 16 weeks on a high fat diet, mice weigh 40% less than in similarly treated wild-type mice

• female mice fed a 60% high fat diet and male mice fed a 45% high fat diet exhibit decreased weight gain compared to similarly treated wild-type mice

decreased circulating insulin level ( J:149373 )

• mice fed a high fat diet exhibit lower fasting insulin serum levels than in similarly treated wild-type mice

decreased circulating cholesterol level ( J:149373 )

• when fed a high fat diet

decreased circulating LDL cholesterol level ( J:149373 )

• when fed a high fat diet, non-HDL serum cholesterol levels are lower than in similarly treated wild-type mice

decreased circulating VLDL cholesterol level ( J:149373 )

• when fed a high fat diet, non-HDL serum cholesterol levels are lower than in similarly treated wild-type mice

decreased circulating triglyceride level ( J:149373 )

• following intragastric bolus of olive oil

increased body temperature ( J:149373 )

• when fed a high fat diet

increased oxygen consumption ( J:149373 )

• increased 7% when fed a high fat diet

improved glucose tolerance ( J:149373 )

• when fed a high fat diet

decreased susceptibility to hyperlipidemia ( J:149373 )

• when fed a high fat diet

adipose tissue

decreased brown fat cell number ( J:149373 )

• when fed a high fat diet

decreased percent body fat/body weight ( J:149373 )

• at 16 weeks on a high fat diet, fat mass is more than 50% lower than in similarly treated wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:149373 )

• at 16 weeks on a high fat diet, mice weigh 40% less than in similarly treated wild-type mice

• female mice fed a 60% high fat diet and male mice fed a 45% high fat diet exhibit decreased weight gain compared to similarly treated wild-type mice

liver/biliary system

decreased susceptibility to hepatic steatosis ( J:149373 )

digestive/alimentary system

abnormal intestinal lipid absorption ( J:149373 )

• when fed an increased amount of fat, less lipids enter circulation compared to wild-type mice