Phenotypes Associated with This Genotype

Genotype
MGI:3848704

• Allelic Composition: Serpinf1^tm1Craw/Serpinf1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:83748 )

♂ • at 3 months of age, heterozygous mutant prostates display a 1.9-fold increase in stromal microvasculature density relative to wild-type prostates

prostate gland epithelial hyperplasia ( J:83748 )

♂ • at 3 months of age, heterozygotes display a less pronounced prostate epithelial hyperplasia relative to homozygous mutant mice, athough the number of PCNA-positive epithelial cells is significantly higher than that observed in wild-type prostate tissues

♂ • by 6 months of age, heterozygotes display moderate nuclear pleiomorphism and hyperchromatic nuclei, indicating a progressive phenotype

reproductive system

abnormal prostate gland morphology ( J:83748 )

♂ • at 3 months of age, heterozygous mutant prostates display a 1.9-fold increase in stromal microvasculature density relative to wild-type prostates

prostate gland epithelial hyperplasia ( J:83748 )

♂ • at 3 months of age, heterozygotes display a less pronounced prostate epithelial hyperplasia relative to homozygous mutant mice, athough the number of PCNA-positive epithelial cells is significantly higher than that observed in wild-type prostate tissues

♂ • by 6 months of age, heterozygotes display moderate nuclear pleiomorphism and hyperchromatic nuclei, indicating a progressive phenotype