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Phenotypes Associated with This Genotype
Genotype
MGI:3848804
Allelic
Composition		 Zfxtm1.1Reiz/Y
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)12Flv mutation (1 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:149654 )
• mature T cells are decreased compared to in wild-type mice
decreased hematopoietic stem cell number ( J:149654 )
• mice exhibit a reduction in hematopoietic stem cells and specifically self-renewing long-term hematopoietic stem cells compared to in wild-type mice
abnormal hematopoietic system physiology ( J:149654 )
• maintenance of adult hematopoietic cells is abolished compared to in wild-type mice

immune system
decreased T cell number ( J:149654 )
• mature T cells are decreased compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory