Phenotypes Associated with This Genotype

Genotype
MGI:3849076

• Allelic Composition: Wif1^tm1Dmth/Wif1^tm1Dmth
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Wif1^tm1Dmth/Wif1^tm1Dmth mice are susceptible to spontaneous and radiation-induced osteosarcoma

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:149607 )

• median survival time was reduced in a radiocarcinogen model using ⁴⁵Ca

neoplasm

increased sarcoma incidence ( J:149607 )

• 2 of 13 mice developed spontaneous sarcomas; one in the limb arising adjacent to bone and one osteosarcoma

increased osteosarcoma incidence ( J:149607 )

• seen in 1 of 13 mice at 56 weeks of age

increased incidence of induced tumors ( J:149607 )

• median latency of tumor onset was shorter and median survival time was reduced in a radiocarcinogen model using ⁴⁵Ca to induce osteosarcomas

skeleton

increased osteosarcoma incidence ( J:149607 )

• seen in 1 of 13 mice at 56 weeks of age