Phenotypes for Jag1 Six1 MGI:3849174 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Jag1^Mhdahtu/Jag1⁺ Six1^Cwe/Six1⁺
Genetic Background	C3HeB/FeJ-C3HeB/FeJ-Jag1^Htu Six1^Cwe

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1^Mhdahtu mutation (2 available); any Jag1 mutation (78 available)
Six1^Cwe mutation (1 available); any Six1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal inner ear canal morphology ( J:149467 )

• anterior and posterior canals are truncated compared to in wild-type mice

• however, lateral canals are normal

abnormal posterior semicircular canal morphology ( J:149467 )

• truncated

abnormal crista ampullaris morphology ( J:149467 )

• mice lack cristae unlike wild-type mice

abnormal superior semicircular canal morphology ( J:149467 )

• truncated

behavior/neurological

head bobbing ( J:149467 )

circling ( J:149467 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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