Phenotypes Associated with This Genotype

Genotype
MGI:3849329

• Allelic Composition: Kmt2a^tm1Brad/Kmt2a^tm1Brad; Commd10^{Tg(Vav1-icre)A2Kio}/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased common myeloid progenitor cell number ( J:149811 )

• there is about a 2-fold reduction in myeloid CFU number isolated from E13.5 fetal livers

• a similar reduction in CFU is observed with bone marrow cells

decreased pre-B cell number ( J:149811 )

• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow

abnormal bone marrow cell physiology ( J:149811 )

• mutant HSC bone marrow cells give less then a 1% long-term reconstitution when transplanted at a 1:1 ratio with wild-type bone marrow into irradiated mice

• mutant HSC bone marrow cells give only a 2% long-term reconstitution when transplanted at a 10:1 ratio

• poor reconstitution is observable as little as 4 weeks after transfer

immune system

decreased pre-B cell number ( J:149811 )

• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow