Phenotypes Associated with This Genotype

Genotype
MGI:3849562

• Allelic Composition: Vegfa^tm1.1Nagy/Vegfa^tm1.1Nagy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:64090 )

• mice die between E14.5 and E12.5

cardiovascular system

abnormal truncus arteriosus septation ( J:64090 )

abnormal heart morphology ( J:64090 )

• excess endothelial cells are present in the heart unlike in wild-type hearts

abnormal myocardial trabeculae morphology ( J:64090 )

• the trabeculation of the inner wall is more elaborate than in wild-type mice

thin ventricle myocardium compact layer ( J:64090 )

• the compact layers of both ventricles are reduced compared to in wild-type mice

abnormal coronary vessel morphology ( J:64090 )

• coronary vessels are enlarged and often open into the ventricular cavities or are blind-ended unlike in wild-type mice

• enlarged coronary vessels are frequently observed on the epicardial surface unlike in wild-type mice

abnormal interventricular septum morphology ( J:64090 )

enlarged heart ( J:64090 )

thin ventricular wall ( J:64090 )

homeostasis/metabolism

edema ( J:64090 )

• embryos are edematous

immune system

abnormal lymphatic vessel morphology ( J:64090 )

• the developing jugular lymph sacs are dilated compared to in wild-type mice

muscle

abnormal myocardial trabeculae morphology ( J:64090 )

• the trabeculation of the inner wall is more elaborate than in wild-type mice

thin ventricle myocardium compact layer ( J:64090 )

• the compact layers of both ventricles are reduced compared to in wild-type mice

growth/size/body

enlarged heart ( J:64090 )