Phenotypes Associated with This Genotype

Genotype
MGI:3850392

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Tg(Mpz-cre)#Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

osseous metaplasia ( J:63264 )

• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa

increased renal carcinoma incidence ( J:63264 )

• 10% of mice develop carcinoma in situ in the kidney

increased neurofibrosarcoma incidence ( J:63264 )

increased osteosarcoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

increased odontoma incidence ( J:63264 )

• 6% of mice develop odontomas and odontosarcomas

increased odontosarcoma incidence ( J:63264 )

• 6% of mice develop odontomas and odontosarcomas

increased osteoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

skeleton

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

increased osteosarcoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

increased osteoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

abnormal osteoblast morphology ( J:63264 )

• osteoblastic hyperplasia

nervous system

increased neurofibrosarcoma incidence ( J:63264 )

abnormal Schwann cell morphology ( J:63264 )

• 8% of mice exhibit Schwann cell hyperplasia

renal/urinary system

increased renal carcinoma incidence ( J:63264 )

• 10% of mice develop carcinoma in situ in the kidney

abnormal renal tubule morphology ( J:63264 )

• mice exhibit renal tubular cell hyperplasia

craniofacial

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia