Phenotypes Associated with This Genotype

Genotype
MGI:3850450

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:132943 )

• following adenoviral cre treatment, 5 of 30 mice develop malignant mesotheliomas-like thoracic tumors

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

endocrine/exocrine glands

abnormal bile duct epithelium morphology ( J:223215 )

• mice develop mild focal proliferation of cryokeratin-positive biliary epithelial cells 2 months following Ad-Cre injection

liver/biliary system

abnormal bile duct epithelium morphology ( J:223215 )

• mice develop mild focal proliferation of cryokeratin-positive biliary epithelial cells 2 months following Ad-Cre injection

enlarged liver ( J:132943 )

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

growth/size/body

enlarged liver ( J:132943 )

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus