Phenotypes Associated with This Genotype

Genotype
MGI:3851183

• Allelic Composition: Cplx3^tm1Bros/Cplx3^tm1Bros; Cplx4^tm1Bros/Cplx4^tm1Bros
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina photoreceptor morphology ( J:150490 )

• many photoreceptor ribbon synapse complexes are disintegrated

• in adults photoreceptor terminals containing spherical free floating ribbons are seen

disorganized retina outer plexiform layer ( J:150490 )

abnormal eye electrophysiology ( J:150490 )

• significant reduction in b-wave amplitudes and prolongation of b-wave implicit times at all light intensities

• slight increase in a-wave amplitudes and prolongation of a-wave implicit times at medium light intensities

• peak power but not peak frequency of oscillatory potentials is reduced

abnormal vision ( J:150490 )

• mice take more time to reach the visible platform in a cued platform test in the Morris water maze; however, mice show a normal learning curve in this test and normal motor function indicating the delay is due to impaired vision

• in contrast, performance in a visual cliff test is similar to controls

nervous system

abnormal retina photoreceptor morphology ( J:150490 )

• many photoreceptor ribbon synapse complexes are disintegrated

• in adults photoreceptor terminals containing spherical free floating ribbons are seen