Phenotypes Associated with This Genotype

Genotype
MGI:3851786

• Allelic Composition: Tg(Myh6-MEF2A)1Jmol/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

pulmonary vascular congestion ( J:111573 )

• medium expressing mice show greater pulmonary congestion measured by lung weight to tibia length compared to controls after 2 weeks of transverse aortic constriction

increased myocardial fiber size ( J:111573 )

• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction

enlarged heart ( J:111573 )

• medium expressing mice have enlarged hearts compared to controls after 2 weeks of transverse aortic constriction

increased heart weight ( J:111573 )

• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction

abnormal heart left ventricle morphology ( J:111573 )

dilated heart left ventricle ( J:111573 )

• medium expressing mice show greater left ventricle dilation compared to controls after 2 weeks of transverse aortic constriction; mice show more dilation than wild-type and low expressing animals which display concentric hypertrophy

decreased heart ventricle muscle contractility ( J:111573 )

• medium expressing mice exhibit greater decompensation in ventricular performance compared to controls after 2 weeks of transverse aortic constriction

muscle

increased myocardial fiber size ( J:111573 )

• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction

decreased heart ventricle muscle contractility ( J:111573 )

• medium expressing mice exhibit greater decompensation in ventricular performance compared to controls after 2 weeks of transverse aortic constriction

respiratory system

pulmonary vascular congestion ( J:111573 )

• medium expressing mice show greater pulmonary congestion measured by lung weight to tibia length compared to controls after 2 weeks of transverse aortic constriction

growth/size/body

enlarged heart ( J:111573 )

• medium expressing mice have enlarged hearts compared to controls after 2 weeks of transverse aortic constriction

increased heart weight ( J:111573 )

• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction