Analysis Tools
hematopoietic system
|
• nave CD4 T cells cultured under Th17-polarizing conditions produce about 3-fold less Th17 cells
• there is also less suppression of IL-21 producing T cells under Th17 polarizing conditions
|
immune system
|
• nave CD4 T cells cultured under Th17-polarizing conditions produce about 3-fold less Th17 cells
• there is also less suppression of IL-21 producing T cells under Th17 polarizing conditions
|
homeostasis/metabolism
|
• homozygotes subjected to renal ischemia-reperfusion (IR) under sevoflurane anesthesia display significantly higher plasma creatinine levels than similarly treated wild-type mice
|
|
• sevoflurane fails to protect homozygotes against IR-induced renal tubular necrosis, unlike in wild-type controls
• sevoflurane also fails to protect primary cultures of renal proximal tubules against H2O2-induced necrosis, unlike in wild-type controls
|
|
• homozygotes are not protected against renal IR injury under anesthesia with sevoflurane (a volatile anesthetic), unlike similarly treated wild-type controls
|
renal/urinary system
|
• homozygotes are not protected against renal IR injury under anesthesia with sevoflurane (a volatile anesthetic), unlike similarly treated wild-type controls
|
|
• homozygotes subjected to renal IR injury under sevoflurane anesthesia exhibit more severe renal tubular necrosis than similarly treated wild-type controls
• in culture, sevoflurane-treated proximal tubule cells isolated from homozygous mutant mice are not protected against H2O2-induced necrosis, unlike similarly treated wild-type proximal tubule cells
|
