Phenotypes Associated with This Genotype

Genotype
MGI:3852116

• Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc; Tg(Slc6a3-icre)1Fto/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150544 )

N • mutant and control mice show similar acquisition and motivation to self-administer cocaine

nervous system

nervous system phenotype ( J:150544 )

N • spontaneous activity (firing rates) of dopamine neurons in the ventral tegmental area (VTA) is similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150544 )

N • circulating glucocorticoid levels are normal under basal and stress conditions