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Phenotypes Associated with This Genotype
Genotype
MGI:3852116
Allelic
Composition
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Slc6a3-icre)1Fto/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Slc6a3-icre)1Fto mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutant and control mice show similar acquisition and motivation to self-administer cocaine

nervous system
N
• spontaneous activity (firing rates) of dopamine neurons in the ventral tegmental area (VTA) is similar to controls

homeostasis/metabolism
N
• circulating glucocorticoid levels are normal under basal and stress conditions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory