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Phenotypes Associated with This Genotype
Genotype
MGI:3852531
Allelic
Composition		 Nfkb1tm1Brv/Nfkb1tm1Brv
Nfkb2tm1Brv/Nfkb2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Brv mutation (0 available); any Nfkb1 mutation (102 available)
Nfkb2tm1Brv mutation (0 available); any Nfkb2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal bone structure ( J:44112 )
• mice exhibit only subtle changes in bone structure
abnormal osteoclast differentiation ( J:44112 )
• osteoclast differentiation is arrested before fusion
decreased osteoclast cell number ( J:44112 )
• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

immune system
abnormal osteoclast differentiation ( J:44112 )
• osteoclast differentiation is arrested before fusion
decreased osteoclast cell number ( J:44112 )
• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

hematopoietic system
abnormal osteoclast differentiation ( J:44112 )
• osteoclast differentiation is arrested before fusion
decreased osteoclast cell number ( J:44112 )
• no mature osteoclasts are detected in cultures of spleen cells unlike those of wild-type cell

cellular
abnormal osteoclast differentiation ( J:44112 )
• osteoclast differentiation is arrested before fusion

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory