Phenotypes Associated with This Genotype

Genotype
MGI:4353989

• Allelic Composition: Rbl1^tm1Mru/Rbl1^tm1Mru
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:92520 )

• mice exhibit an increase in the rate of progenitor regeneration

• however, neurogenesis in the olfactory bulb is normal

abnormal postnatal subventricular zone morphology ( J:92520 )

• more proliferating cells are found in the ventricular subependyma than in wild-type mice

• the number of apoptotic cells in the ventricular subependyma is increased compared to in wild-type mice

increased neuronal precursor cell number ( J:92520 )

• mice exhibit increased neuronal precursor numbers due to increased proliferation

• cultured E10 telencephalic neuroepithelia produces more primary neurospheres than cultures from wild-type mice

• adult brain cultures produce 2-fold more primary neurospheres than cultures from wild-type mice independent of cell density

• mice exhibit a higher number of slowly dividing neural precursor cells compared to in wild-type mice

cellular

abnormal neuronal precursor proliferation ( J:92520 )

• mice exhibit an increase in the rate of progenitor regeneration

• however, neurogenesis in the olfactory bulb is normal